New dupuytren’s disease patent is a major milestone

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Ventoux Biosciences Secures U.S. Patent for Novel Therapy Targeting Dupuytren’s Disease and Immune-Fibrotic Disorders

San Diego, CA — September 23, 2025Ventoux Biosciences, a biotechnology company developing disease-modifying therapies for fibrotic conditions, today announced the issuance of a U.S. patent covering methods for treating immune-fibrotic disorders, including Dupuytren’s disease. The patent provides protection through 2044, further strengthening Ventoux’s intellectual property portfolio and positioning the company to advance first-in-class therapies in an area of high unmet need.

Dupuytren’s disease affects millions of people worldwide and is over four times more common than rheumatoid arthritis. Despite its prevalence and impact on hand function and quality of life, there are no approved disease-modifying therapies — only invasive or temporary interventions. Ventoux’s approach seeks to change this paradigm by addressing the underlying biological pathways that drive fibrosis.

“This is a major milestone for Ventoux Biosciences,” said Kurt Harrington, CEO and a patient living with Dupuytren’s disease. “It validates our novel approach to targeting the drivers of fibrosis and underscores our commitment to bringing transformative therapies to patients. For too long, individuals with Dupuytren’s and related conditions have had few options. We believe our platform has the potential to deliver meaningful, disease-modifying outcomes.”

Ken Lipson, PhD, Chief Scientific Officer, added: “The patent highlights the innovative mechanism behind our therapy, which focuses on modulating key immune-fibrotic pathways involved in disease progression. With this protection in place, we are well positioned to advance our lead program toward preclinical proof-of-concept and ultimately clinical development.”

“Dupuytren’s disease remains a challenging condition for many patients, particularly given the lack of approved therapies that alter its underlying biology,” said Dr. Gary M. Pess, MD, Senior Managing Partner and Medical Director at Central Jersey Hand Surgery and a leading expert in Dupuytren’s treatment. “Ventoux Biosciences’ recent patent and ongoing work are exciting because they move us closer to treatments that could modify disease progression rather than only treating contracture. This has the potential to change lives by preserving hand function, avoiding invasive interventions, and reducing burden over the long term.”

Ventoux Biosciences’ platform is designed to be applicable across multiple fibrotic disorders, many of which currently lack effective treatments. By focusing on the intersection of immune response and fibrosis, the company aims to unlock new therapeutic possibilities not only for Dupuytren’s disease but for other chronic fibrotic conditions where patients face limited or no options today.

The patent issuance follows a period of growing recognition for Ventoux Biosciences, including industry awards for innovation and leadership in immune-fibrotic research. The company continues to advance its programs, strengthen its scientific partnerships, and prepare for the next phase of development.

About Ventoux Biosciences
Ventoux Biosciences is pioneering disease-modifying therapies for immune-fibrotic disorders, starting with Dupuytren’s disease—one of the most common yet underserved fibrotic conditions. Led by a seasoned biopharma team, Ventoux is advancing a platform that addresses the underlying biological pathways that drive fibrosis with a goal of  delivering safe, effective, and lasting treatments. For more information, visit www.VentouxBio.com.

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Johnny Randel

Johnny Randel is a senior finance executive who has more than 30 years of experience in financial institutions including over 17 in private equity.

Mr. Randel recently retired as the Chief Financial Officer (“CFO”) of StepStone Group. Inc (Nasdaq: STEP), a global private markets specialist firm delivering tailored investment solutions, advisory services, and impactful, data-driven insights to the world’s investors with $678B of capital responsibility. Mr. Randel spent over 13 years leading the corporate and investment finance and accounting teams and was the CFO for the lead up and execution of the company’s initial public offering in 2020.

Previously, Mr. Randel held the role of Chief Financial Officer and Chief Operating Officer at Citigroup Private Equity overseeing financial and operational activities for the company and its coinvestment, mezzanine, and fund of fund investment programs. Mr. Randel also held a previous role as Assistant Treasurer within Citigroup Inc.’s Treasury department where he managed rating agency relationships and fixed income client relations. Mr. Randel also held various finance roles supporting corporate finance and strategy over the course of his career. Mr. Randel received his B.G.S. from the University of Kansas and MBA from the University of Southern California.

Matt Cravets

Mr. Cravets is an industry leader in biostatistics with extensive experience in program design and analysis. He currently serves as the Senior Vice President of Biometrics at Gossamer Bio. Prior to joining Gossamer Bio, Mr. Cravets was Vice President of Biometrics at Heron Therapeutics Inc. from 2016 to 2018, where he played a key role in the late-stage development programs for Zynrelef for the treatment post-surgical pain and Cinvanti for the prevention of chemotherapy induced nausea and vomiting. Before joining Heron, Mr. Cravets was Executive Director of Biometrics at Receptos Inc. from 2014 to 2016, where he built the biostatistics and data management functions while contributing to mid- and late-stage development programs for ozanimod (Zeposia) in multiple sclerosis (MS) and inflammatory bowel diseases (IBD). Before joining Receptos, Mr. Cravets was the head of biostatistics at Ardea Biosciences from 2011-2014, building the biostatistics function while also making significant contributions to the designs and analyses of late-stage studies of lesinurad (Zurampic) for the treatment of gout. From 2003-2011 Mr. Cravets served in roles of increasing responsibility in the biostatistics group at Biogen Idec Inc., contributing to the successful regulatory approvals of rituximab (Rituxan) in both rheumatoid arthritis (RA) and chronic lymphocytic leukemia (CLL). From 1996 to 2003, Mr. Cravets was in the biostatistics group at Amgen, Inc., working on multiple products across various neurology, rheumatology, cardiovascular, and bone disease indications. Mr. Cravets began his career in the pharmaceutical products division of Abbott Laboratories in 1994 after completing his master’s degree in statistics at the University of Michigan and his bachelor’s degree in mathematics at UCLA.

Latha Satish, M.Sc., M.Phil, Ph.D.

Dr. Satish is a trained biotechnologist with several years of experience in cell and molecular biology. Dr. Satish’s interest has been in skin research with a special focus on skin inflammation, infection, and fibrosis. The other arm of Dr. Satish’s research has been to study the molecular determinants of palmar fascial disease, Dupuytren’s contracture.

Her long-term interest has been to develop therapeutic agents to help alleviate the pain and distress of patients with Dupuytren’s. Her studies on Dupuytren’s disease were funded by a private donor, which moved the research forward to study this disease in an animal model, which was not feasible earlier. Dr. Satish’s research on Dupuytren has identified small molecules that can be used as a target to intervene with the progression and development of the disease.

Dr. Satish received her Ph.D. from a prestigious institute in India and did her post-doctoral training at the University of Pittsburgh. Currently, Dr. Satish serves as a faculty at the Division of Asthma Research, Cincinnati Children’s Hospital; named as the top hospital in the US. At Cincinnati Children’s, Dr. Satish researches Atopic Dermatitis, a chronic inflammatory skin disease affecting children and adults. Dr. Satish has published over 50 articles in peer-reviewed journals, review articles and book chapters.

Dr. Keith Denkler

Dr. Denkler is an accomplished, board certified plastic surgeon with expertise in aesthetic and reconstructive surgery. Dr. Denkler is a clinical professor of plastic surgery at UCSF and has a private practice in Marin County.

He is internationally renowned for his use of multiple approaches in treating the debilitating and disabling effects of palmar fibromatosis (Dupuytren disease). Dr. Denkler is an expert in needle aponeurotomy (NA), a minimally invasive procedure that uses subcutaneous needles to release the contracture as well as use of subcutaneous injection of collagenase. He has treated over 10,000 Dupuytren’s fingers, authored >35 publications and book chapters, presented internationally and domestically and is often cited for expert opinion in national and international news discussing Dupuytren’s. HIs pioneering investigational work documenting the safety of epinephrine with local anesthesia contributed to the origination of “wide-awake hand surgery”.

Dr. Denkler trained at prestigious medical institutions in the United States and Europe. He attended Baylor College of Medicine in Houston, Texas, followed by residency training in plastic and reconstructive surgery with the Cronin, Bauer, and Biggs group, also in Houston. Additionally, Dr. Denkler completed a hand surgery fellowship with Dr. Eugene Kilgore in San Francisco and one year of fellowship training in craniofacial surgery with Dr. Paul Tessier in Paris, France.

Dr. daiva bajorunas

Daiva Bajorunas MD is an endocrinologist with more than 25 years of experience in the biopharmaceutical industry.  She has a strong interest in advancing therapeutic options for conditions of significant unmet medical need. 

For the past decade, Daiva has been engaged as a consultant to the pharmaceutical industry, currently as Founder and Principal, DBMD Consulting, and previously as Chief Medical Officer / Chief Scientific Officer for Vault Bioventures. She has provided her expertise to enhance large, mid-size and small pharmaceutical company product development, clinical/regulatory, and life cycle strategies for both drugs and devices, including oral, transdermal, injectable and inhalative delivery systems, working across multiple therapeutic areas and geographies. She has considerable experience chairing Data Safety Monitoring Boards.   

In the past she held various R&D positions of increasing responsibility at Rhone-Poulenc Rorer, BMS, Aventis (acquired by Sanofi), and Kos Pharmaceuticals (acquired by Abbott). Before she joined industry, she held academic appointments at Memorial Sloan-Kettering Cancer Center and Cornell University Medical College (CUMC), and was Director of Clinical Care, Endocrinology Service, Memorial Hospital (MH), New York, NY. Daiva received her MD degree at the University of Michigan Medical School, did her residency training at St. Vincent’s Hospital & Medical Center in NY, her metabolism fellowship at Stanford University Medical Center, CA and her endocrinology fellowship at MH/CUMC, NY.